--- title: Invitrolize | In-vitro Human-relevant respiratory safety description: Modelo 3D ALIsens® para evaluar la seguridad de sustancias inhalables, previniendo riesgos respiratorios y fortaleciendo las presentaciones regulatorias con datos relevantes. image: https://invitrolize.com/hubfs/Logo%20invitrolize%20HubSpot.jpg --- [Skip to main content](https://invitrolize.com#main-content) [![Invitrolize](https://invitrolize.com/hs-fs/hubfs/Branding/Logos/logo-01.png?width=169&height=50&name=logo-01.png) ![Invitrolize](https://invitrolize.com/hs-fs/hubfs/Branding/Logos/logo-01.png?width=169&height=50&name=logo-01.png) ![Invitrolize](https://invitrolize.com/hs-fs/hubfs/Branding/Logos/logo-01.png?width=169&height=50&name=logo-01.png) ![Invitrolize](https://invitrolize.com/hs-fs/hubfs/Branding/Logos/logo-01.png?width=169&height=50&name=logo-01.png)](https://invitrolize.com) - [Start here](https://invitrolize.com/respiratory-sensitization-regulatory-problem-no-solution-until-now) - [ALIsens®](https://invitrolize.com/alisens-in-vitro-lung-models-for-inhalation-safety) - Show submenu for Services Services - [For CROs](https://invitrolize.com/strengthen-your-cro-offering-with-invitrolize) - [For Industry](https://invitrolize.com/regulatory-grade-respiratory-sensitization-for-industry) - [Events](https://invitrolize.com/events) - [About us](https://invitrolize.com/inside-invitrolize-get-to-know-us) Open main navigation Close main navigation - [Start here](https://invitrolize.com/respiratory-sensitization-regulatory-problem-no-solution-until-now) - [ALIsens®](https://invitrolize.com/alisens-in-vitro-lung-models-for-inhalation-safety) - Show submenu for Services Services - Services - [For CROs](https://invitrolize.com/strengthen-your-cro-offering-with-invitrolize) - [For Industry](https://invitrolize.com/regulatory-grade-respiratory-sensitization-for-industry) - [Events](https://invitrolize.com/events) - [About us](https://invitrolize.com/inside-invitrolize-get-to-know-us) - [Book a Meeting](https://invitrolize.com/demo) [Book a Meeting](https://invitrolize.com/demo) # Human-relevant respiratory safety, built for upcoming regulation ALIsens® is our patented 3D human alveolar *in vitro* model designed to assess the safety of inhalable substances under realistic air–liquid interface exposure conditions.       [Schedule a meeting](https://invitrolize.com/demo) [Explore ALIsens®](https://invitrolize.com/alisens-in-vitro-lung-models-for-inhalation-safety) Companies Featuring ALIsens® in Peer-Reviewed Publications ![RIFM white logo](https://invitrolize.com/hs-fs/hubfs/RIFM%20white%20logo.png?width=200&height=59&name=RIFM%20white%20logo.png) ![PCRM logo white](https://invitrolize.com/hs-fs/hubfs/PCRM%20logo%20white.png?width=128&height=59&name=PCRM%20logo%20white.png) ![BASF-logo](https://invitrolize.com/hs-fs/hubfs/BASF-logo.png?width=311&height=59&name=BASF-logo.png) ![Philip Morris International white logo](https://invitrolize.com/hs-fs/hubfs/Philip%20Morris%20International%20white%20logo.png?width=257&height=59&name=Philip%20Morris%20International%20white%20logo.png) ![Evonik logo white](https://invitrolize.com/hs-fs/hubfs/Evonik%20logo%20white.png?width=257&height=59&name=Evonik%20logo%20white.png) ## How ALIsens® Works ALIsens® combines human lung and immune cell lines in a structured 3D architecture that mimics the alveolar–capillary barrier. Test substances are delivered under controlled air–liquid interface conditions, replicating real inhalation exposure and enabling precise assessment of irritation and sensitization responses. [Discover how it works](https://invitrolize.com/alisens-in-vitro-lung-models-for-inhalation-safety) ## What ALIsens® Enables See how it helps your business manage respiratory and regulatory risks. #### Prevent costly late-stage development failures Identify respiratory hazards early to reduce attrition, avoid sunk R&D costs, and make safer go/no-go decisions sooner. #### Strengthen regulatory submissions Generate human-relevant data designed to support regulatory dossiers as respiratory sensitization becomes mandatory. #### Reduce reputational and recall risk Detect irritation or sensitization risks before market entry, minimizing recalls, litigation, and long-term brand damage. #### Replace or avoid animal testing Use a human cell–based alternative aligned with animal testing bans, internal policies, and ethical requirements. ![Lungs](https://invitrolize.com/hs-fs/hubfs/Website/Generic%20images/Lungs.png?width=1000&height=1000&name=Lungs.png) ## Respiratory risks are often found too late. Traditional models frequently fail to predict respiratory sensitization accurately. When risk is identified late, the consequences are regulatory delays, additional studies and blocked compounds. #### Early, human-relevant data changes that trajectory. Invitrolize develops and applies advanced *in vitro* respiratory models that reflect human biology under realistic exposure conditions.   [Why current models fall short](https://invitrolize.com/respiratory-sensitization-regulatory-problem-no-solution-until-now) ## Scientific Papers Discover how our latest research challenges conventional thinking and opens up new opportunities in the field. If you’re looking to go beyond surface-level information and truly understand what’s next, our papers are your gateway to deeper knowledge and smarter decisions. ![Elsevier\_MMA](https://invitrolize.com/hubfs/Elsevier_MMA.jpg) #### A novel *in vitro* alveolar model ALIsens® for hazard assesment of methyl methacrylate: No evidence for respiratory potencial A newly published peer-reviewed study, written by invitrolize in collaboration with BASF and Evonik, reports that methyl methacrylate (MMA), a widely used industrial chemical, does not show evidence of respiratory sensitisation. Invitrolize Luxembourg [Download the paper](https://invitrolize.com/paper-methyl-methacrylate) ## See how this applies to your case #### Every compound and regulatory context is different. In a scientific demo, we review your needs and show how our models can support your decisions. 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